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  • Association between EEG abnormalities and CSF biomarkers in a Memory Clinic Cohort
    Gregorič Kramberger, Milica ...
    Background: The aim of the study was to describe distinct electroencephalogram (EEG) phenotypes defined after routine visual EEG analysis in a large memory clinic cohort and to investigate their ... relationship to cerebrospinal fluid (CSF) biomarkers. Methods: Patients with Alzheimer's disease (n = 131), mild cognitive impairment (n = 285), subjective cognitive impairment (n = 310), and mixed dementia (n = 29) were assessed clinically with neuroimaging, EEG and CSF investigations. EEG phenotypes were based on frequency of background activity (BA) and presence and degree of episodic abnormalities (EA). Results: BA and EA differed significantly (p < 0.001) between diagnostic groups. A lower CSF amyloid 42/phospho-tau ratio and higher total tau were associated with slower BA (p < 0.01) and a higher degree of EA (p < 0.04). Conclusions: Slowing of BA in combination with EA seems to be related to biological markers of neurodegeneration
    Source: Dementia and geriatric cognitive disorders. - ISSN 1420-8008 (Vol. 36, iss. 5/6, Sep. 2013, str. 319-328)
    Type of material - article, component part
    Publish date - 2013
    Language - english
    COBISS.SI-ID - 1044652
    DOI

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