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Applicability of RPMI 2650 and Calu-3 cell models for evaluation of nasal formulations [Elektronski vir]Sibinovska, Nadica ...The RPMI 2650 and Calu-3 cell lines have been previously evaluated as models of the nasal and airway epithelial barrier, and they have demonstrated the potential to be used in drug permeation ... studies. However, limited data exist on the utilization of these two cell models for the assessment of nasal formulations. In our study, we tested these cell lines for the evaluation of in vitro permeation of intranasally administered drugs having a local and systemic effect from different solution- and suspension-based formulations to observe how the effects of formulations reflect on the measured in vitro drug permeability. Both models were shown to be sufficiently discriminative and able to reveal the effect of formulation compositions on drug permeability, as they demonstrated differences in the in vitro drug permeation comparable to the in vivo bioavailability. Good correlation with the available bioavailability data was also established for a limited number of drugs formulated as intranasal solutions. The investigated cell lines can be applied to the evaluation of in vitro permeation of intranasally administered drugs with a local and systemic effect from solution- and suspension-based formulations.Source: Pharmaceutics [Elektronski vir]. - ISSN 1999-4923 (Vol. 14, issue 2, art.369, 2022, str. 1-19)Type of material - e-article ; adult, seriousPublish date - 2022Language - englishCOBISS.SI-ID - 107048707
Author | Sibinovska, Nadica ... |
Title | Applicability of RPMI 2650 and Calu-3 cell models for evaluation of nasal formulations [Elektronski vir] |
Publication date | 2022-02-06 |
COBISS.SI-ID | 107048707 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
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Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih | P1-0189-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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https://repozitorij.uni-lj.si/IzpisGradiva.php?id=137348 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Sibinovska, Nadica | |
Žakelj, Simon | 22659 |
Trontelj, Jurij | 23420 |
Kristan, Katja, 1975- | 24392 |
Source: Personal bibliographies
and: SICRIS
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