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  • In situ monitoring of electric field distribution in mouse tumor during electroporation
    Kranjc, Matej, 1983- ...
    To investigate the feasibility of magnetic resonance (MR) electric impedance tomography (EIT) technique for in situ monitoring of electric field distribution during in vivo electroporation of mouse ... tumors to predict reversibly electroporated tumor areas. Materials and Methods All experiments received institutional animal care and use committee approval. Group 1 consisted of eight tumors that were used for determination of predicted area of reversibly electroporated tumor cells with MR EIT by using a 2.35-T MR imager. In addition, T1-weighted images of tumors were acquired to determine entrapment of contrast agent within the reversibly electroporated area. A correlation between predicted reversible electroporated tumor areas as determined with MR EIT and areas of entrapped MR contrast agent was evaluated to verify the accuracy of the prediction. Group 2 consisted of seven tumors that were used for validation of radiologic imaging with histopathologic staining. Histologic analysis results were then compared with predicted reversible electroporated tumor areas from group 1. Results were analyzed with Pearson correlation analysis and one-way analysis of variance. Results Mean coverage % standard deviation of tumors with electric field that leads to reversible electroporation of tumor cells obtained with MR EIT (38% % 9) and mean fraction of tumors with entrapped MR contrast agent (41% % 13) were correlated (Pearson analysis, r = 0.956, P = .005) and were not statistically different (analysis of variance, P = .11) from mean fraction of tumors from group 2 with entrapped fluorescent dye (39% % 12). Conclusion MR EIT can be used for determining electric field distribution in situ during electroporation of tissue. Implementation of MR EIT in electroporation-based applications, such as electrochemotherapy and irreversible electroporation tissue ablation, would enable corrective interventions before the end of the procedure and would additionally improve the treatment outcome.
    Source: Radiology. - ISSN 0033-8419 (Vol. 274, iss. 1, Jan. 2015, str. 115-123)
    Type of material - article, component part
    Publish date - 2015
    Language - english
    COBISS.SI-ID - 10729556

    Link(s):

    http://dx.doi.org/10.1148/radiol.14140311
    DOI

source: Radiology. - ISSN 0033-8419 (Vol. 274, iss. 1, Jan. 2015, str. 115-123)
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