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  • The synthesis of (2R)-aziridine-2-carboxylic acid containing dipeptides [Elektronski vir]
    Kuzmič, Samo ; Hrast, Martina ; Frlan, Rok
    Optimized conditions for the synthesis of fully deprotected (2R)-aziridine containing dipeptides are described. Preparation of fully protected N- and C- terminal aziridine containing dipeptides was ... found to be straightforward and high yielding for the majority of compounds, whereas their full deprotection was possible only for C-terminal analogs. Deprotection of N-terminal derivatives using standard procedures of peptide chemistry was found difficult providing only mixtures of unidentifiable products. The described molecules have potential as building blocks in synthetic chemistry, in the chemical biology arena, as covalent modifiers, and as biomarkers.
    Source: Acta chimica slovenica [Elektronski vir]. - ISSN 1580-3155 (Vol. 69, no. 2, 2022, str. 261-270)
    Type of material - e-article ; adult, serious
    Publish date - 2022
    Language - english
    COBISS.SI-ID - 108102659

    Link(s):

    https://journals.matheo.si/index.php/ACSi/article/view/6673
    Digitalna knjižnica Slovenije - dLib.si
    Repository of the University of Ljubljana – RUL
    DOI

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