In this study we screened crude methanol water exctracts 89 different mushroom species for their antigenotoxic and bioantimutagenic activity. The creening was performed with the SOS/umu test and we ...monitored the ability of extracts to inhibit UV induced expression of umuC gene in Salmonella typhimurium TA1535/pSK1002. Seventeen extracts inhibited umuC exoressionby more than 50%. These extracts were further evaluated for the ability to inhibit UV induced mutations in Escherichia coli WP@. Five extracts ( Cortinarius evernius, Rozites caperatus, LActarius vellereus, Russula integra and Pleurotus cornucopiae) inhibited also Uv induced mutations. The study showed that certain mushrooms contain substances with bio-antimutahenic potential. Particularly interesting for further investigation are Pleurotus cornucopiae (Lentinaceae), which was the most effective and species of Russulaceae and Cortinaceae families, which might contain common family specific bio-antimutagenic substance(s).
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