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Vismodegib in locally advanced basal cell carcinoma in SloveniaMesti, Tanja ; Sever, Maša, zdravnica ; Ocvirk, JanjaBackground: Vismodegib is a first-in-class inhibitor of the hedgehog pathway for treatment of locally advanced basal cell carcinoma (laBCC) and metastatic BCC. Objectives: The purpose of this study ... is to report outcomes of patients with laBCC, with basal cell carcinoma nevus syndrome (Gorlin Goltz syndrome [G-G Syn]) treated with vismodegib in routine clinical practice in Slovenia in 8.3-year period. Methods: In this retrospective cohort study, we analyzed baseline characteristics, outcomes, and treatment-related adverse events from locally advanced BCC. The patients were divided into two cohorts: 39 laBCC or multiple BCC patients and 7 patients with G-G Syn who were treated with vismodegib from November 2012 till January 2021. Results: During 100-month period, 46 patients were diagnosed with laBCC (26), multiple BCC (13), and G-G Syn (7), all inappropriate for surgery or radiotherapy. Baseline characteristics: median age was 72.8 years in laBCC + multiple BCC cohort and 47.4 years in G-G Syn cohort. The objective response rate was 80% in laBCC + multiple BCC and 86% in G-G Syn cohort. Disease control rate (DCR) was 95% in laBCC + multiple BCC and 100% in G-G Syn cohort. Median duration of treatment was 9.9 months (range: 1.5-43.1) in laBCC and multiple BCC cohort and 19.5 months (range: 3.6-94.1) in G-G Syn cohort. Majority of treatment-emergent adverse events (TEAEs) in laBCC or multiple BCC cohort were grade 1 or 2 (96%), only 4% of AEs were grade 3. Majority of TEAEs in G-G Syn cohort were also grade 1 or 2 (87%), 13% of AEs were grade 3. No grade 4 or 5 vismodegib-related AEs were reported. Conclusion: Vismodegib has shown meaningful efficacy with DCR from 95% to 100% in patients with laBCC, multiple BCC, and G-G Syn in Slovenia. TEAEs were successfully alleviated with multidisciplinary approach and early supportive care.Source: Dermatology. - ISSN 1018-8665 (Vol. 239, no. 1, 2023, str. 158-164)Type of material - article, component partPublish date - 2023Language - englishCOBISS.SI-ID - 117583107
Author | Mesti, Tanja ; Sever, Maša, zdravnica ; Ocvirk, Janja |
Title | Vismodegib in locally advanced basal cell carcinoma in Slovenia |
Publication date | 2022-07-27 |
COBISS.SI-ID | 117583107 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
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Napovedni dejavniki poteka bolezni in odgovora na zdravljenje pri različnih vrst raka | P3-0321-2020 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Files that belong to the publication
Link |
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https://karger.com/drm/article-pdf/239/1/158/3915859/000525612.pdf |
https://dirros.openscience.si/IzpisGradiva.php?id=15459 |
Costs of publication
Cost type | Total cost | Payments |
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APC – Article Processing Charge | 3690.26 € |
3690.26 € : Onkološki inštitut Ljubljana |
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Mesti, Tanja | 32614 |
Sever, Maša, zdravnica | |
Ocvirk, Janja | 13541 |
Source: Personal bibliographies
and: SICRIS
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