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Interactome of PTH-Regulated miRNAs and their predicted target genes for Investigating the epigenetic effects of PTH (1–34) in bone metabolism [Elektronski vir]Vrščaj, Lucija Ana ; Marc, Janja ; Ostanek, Barbara, 1972-Osteoporosis is a metabolic bone disease that mostly affects the elderly. A lot of drugs are available, mostly with an antiresorptive effect but just a few with an osteoanabolic effect, meaning they ... promote bone building. PTH (1-34) or teriparatide is an osteoanabolic drug, but its efficacy varies between individuals. We performed a literature review and extracted a dataset of 62 microRNAs (miRNAs) from 10 different studies; predicted miRNA target interactions (MTIs) were obtained with the help of four software tools: DIANA, miRWalk, miRDB and TargetScan. With the construction of an interactome of PTH-regulated miRNAs and their predicted target genes, we elucidated miR-146a-5p, miR-551b-5p, miR-205-3p, miR-33a-3p, miR-338-5p as miRNAs with the most interactions and miR-410-3p as the miRNA targeting bone-related pathways with the highest significance. These miRNAs could help in further understanding the mechanism of action of PTH on bone metabolism and osteoporosis. They also have the potential for novel network-based biomarkers for osteoporosis treatment efficacy and safety and as new therapeutic targets.Source: Genes [Elektronski vir]. - ISSN 2073-4425 (Vol. 13, iss. 8, art. 1443, 2022, str. 1-15)Type of material - e-article ; adult, seriousPublish date - 2022Language - englishCOBISS.SI-ID - 118226947
Author
Vrščaj, Lucija Ana |
Marc, Janja |
Ostanek, Barbara, 1972-
Topics
Osteoporoza |
Zdravljenje |
zdravljenje osteoporoze |
mikroRNA |
paratiroidni hormon |
teriparatid |
omrežje |
biomarker za obogatitev genov |
biološka pot |
osteoporosis |
osteoporosis treatment |
microRNA |
parathyroid hormone |
teriparatide |
network |
Cytoscape |
biological pathway |
gene enrichment biomarker
Author | Vrščaj, Lucija Ana ; Marc, Janja ; Ostanek, Barbara, 1972- |
Title | Interactome of PTH-Regulated miRNAs and their predicted target genes for Investigating the epigenetic effects of PTH (1–34) in bone metabolism [Elektronski vir] |
Publication date | 2022-08-13 |
COBISS.SI-ID | 118226947 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Celostna karakterizacija zadetkov analiz GWAS - pot do novih terapevtskih tarč za anabolno zdravljenje osteoporoze (GWASforAna) | J3-1759-2019 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Geni, hormonske in osebnostne spremembe pri metabolnih motnjah | P3-0298-2019 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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https://www.mdpi.com/2073-4425/13/8/1443 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=138758 |
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Database name | Field | Year |
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Vrščaj, Lucija Ana | 53726 |
Marc, Janja | 12189 |
Ostanek, Barbara, 1972- | 18154 |
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