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Treatment outcomes and relative dose intensity of chemotherapy in patients with advanced Hodgkin lymphomaRožman, Samo ...The present retrospective study was undertaken to investigate the association of relative dose intensity (RDI) with the outcome of patients with advanced stage Hodgkin lymphoma (HL) receiving ABVD ... (doxorubicin, bleomycin, vinblastine, dacarbazine) and escalated BEACOPP regimens (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone). A total of 114 patients with HL treated between 2004 and 2013 were enrolled for evaluation. The association of variables with overall survival (OS) and progression-free survival (PFS) was analysed using univariate and multivariate Cox proportional hazards models. The median age of patients was 39 years, and the majority were male and had stage IV disease. A total of 54 patients received ABVD and 60 received BEACOPP chemotherapy with 24 and four deaths, respectively. Patients in the BEACOPP group were significantly younger with lower Charlson comorbidity index (CCI) and better performance status in comparison with the ABVD group, making the comparison of groups not possible. In the ABVD group, RDI was not significantly associated with OS (P=0.590) or PFS (P=0.354) in a multivariate model where age was controlled. The low number of events prevented this analysis in the BEACOPP group. The age of patients was strongly associated with both OS and PFS; all statistically significant predictors for OS and PFS from univariate analyses (chemotherapy regimen, CCI, RDI, performance status) lost their effect in multivariate analyses where age was controlled. Based on these observations, it was concluded that RDI was not associated with OS or PFS after age is controlled, neither in all patients combined nor in the ABVD group.Source: Oncology Letters. - ISSN 1792-1074 (Vol. 24, no. 3, 2022, str. 320-1-320-7)Type of material - article, component partPublish date - 2022Language - englishCOBISS.SI-ID - 118357251
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Author | Rožman, Samo ... |
Title | Treatment outcomes and relative dose intensity of chemotherapy in patients with advanced Hodgkin lymphoma |
Publication date | 2022-07-19 |
COBISS.SI-ID | 118357251 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
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Napovedni dejavniki poteka bolezni in odgovora na zdravljenje pri različnih vrst raka | P3-0321-2020 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Rožman, Samo | 36599 |
Jezeršek Novaković, Barbara | 12022 |
Ružić Gorenjec, Nina, 1986- | 33230 |
Novaković, Srdjan | 08007 |
Source: Personal bibliographies
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