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Študij vpliva in deleža razgrejaval na fizikalno-tehnološke lastnosti pelet izdelanih v hitrem mešalniku = The study of influence of disintegrant amount and type on physico-technological properties of the pellets produced in a high shear mixer : diplomska naloga
Leskošek, Tanja
Pelete so majhni okrogli delci, katerih uporaba se je razmahnila na stevilna podroèjaČ medicina, farmacija, homeopatija, agrokultura in prehrambena industrija. Izdelava ogrodnih pelet v hitrem ...mesalniku je za farmacevtsko industrijo zaradi komparativno majhnih investicijskih stroskov zelo zanimiva. V okviru diplomske naloge smo poskusali resiti problem neustrezne razpadnosti pelet, ki vpliva na poèasnejse sprosèanje vgrajene zdravilne uèinkovine. Izdelali smo ogrodne pelete z uporabo dveh modelnih uèinkovin, dobro in tezko topne, v hitrem mesalniku. V pelete smo vkljuèili razgrajevala razliènih tipovin koncentracij. Namen dela je bil ugotoviti in izbrati optimalno formulacijo z ustreznim tipom in delezem razgrajevala z namenom hitrega raztapljanja uèinkovine ob sprejemljivih fizikalno - tehnoloskih lastnostih izdelanih pelet. Uporabljena razgrajevala so bila naslednjaČ natrijev karmezolat (0.2%, 2%, 5%), natrijev karboksimetilskrob (2%, 4%, 6.7%), kalijevpolakrilat (5%, 10%), krospovidon (2%, 5%), kaolin (10%, 20%, 22.8%), skrob (5%, 10%), magnezijev hidrogenkarbonat (10%, 20%), bentonit (5%, 10%), smukec (5%, 10%), barijev sulfat (10%, 20%). Peletam smo doloèili velikost in njihovo porazdelitev, krusljivost, okroglost, nasipno, zbito, teoretièno in pravo gostoto. Spremljali smo porabo tekoèine za aglomeriranje ter èas porabljen za posamezne faze izdelave v hitrem mesalniku. Najpomembnejsi del nase naloge pa je bil test hitrosti raztapljanja uèinkovine iz ogrodnih pelet.Izdelane pelete smo ocenili makroskopsko in mikroskopsko.
Type of material - undergr. thesis
Publication and manufacture - Ljubljana : [Leskošek T.], 2002
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