Background: Individual B vitamins have many favorable effects on the skin and are common cosmetic ingredients. However, their formulation is demanding due to stabil-ity issues, which consequently ...affect the products’ quality.Aims: We aimed to determine the quality (labeling accuracy, content determination, and content- related quality control) and stability under long-term and accelerated storage conditions of a representative sample of commercial cosmetics contain-ing the most common B vitamins-nicotinamide, dexpanthenol, pyridoxine, and cyanocobalamin.Methods:Cyanocobalamin was determined by a previously published stability- indicating HPLC– diode array detector (DAD) method for the simultaneous determi-nation of all hydrophilic vitamins. This method was additionally simplified and adjusted for the time-effective analysis of nicotinamide, dexpanthenol, and pyridoxine. Both methods were properly validated.Results: All labeled B vitamins were present in the 36 tested products, mostly in con-tents, reported effective on the skin. Thus, a straightforward correlation between vitamin contents and product prices were not observed. The content- related quality control of eight products, which quantitively specify their content, revealed signifi-cantly lower nicotinamide contents (47% and 57%) in two products and appropriate or higher nicotinamide (102%–112%) and dexpanthenol (100%–104%) contents than declared in the remaining products. The 6- month long-term and accelerated stability studies demonstrated the products’ physical stability, but also revealed dexpanthenol, pyridoxine, and cyanocobalamin degradation, while nicotinamide was mostly stable in the tested products. Conclusions:The obtained results provide an inside into the quality of commercial vi-tamin B cosmetics and highlight the importance of stability testing in the formulation of quality, efficient, and safe cosmetics.
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https://onlinelibrary.wiley.com/doi/10.1111/jocd.15321
