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Izdelava in vrednotenje hitro disperzibilnih praškastih formulacij slabo vodotopnih antioksidantov koencima Q10 in resveratrola = Production and characterisation of rapidly dispersible powders with poorly water-soluble antioxidants coenzyme Q10 and resveratrol : magistrska naloga : master's thesis : industrijska farmacijaHren, Anja, farmacevtkaNizka peroralna biološka uporabnost kot posledica nizke topnosti učinkovin v vodi predstavlja vedno večji izziv. Eden izmed pristopov, kako izboljšati raztapljanje in s tem biološko uporabnost slabo ... vodotopnih učinkovin, je tudi izdelava različnih formulacij na osnovi lipidov. Slednje so lahko v obliki emulzij ali talin, za pretvorbo v trdno stanje pa lahko uporabimo pristope, kot so (mikro)kapsuliranje, direktna adsorpcija na mezoporozne nosilce, granuliranje in druge. Namen magistrske naloge je bil izdelati trdno formulacijo slabo vodotopnih antioksidantov resveratrola in koencima Q10, ki se bo hitro dispergirala v vodnem mediju in izboljšala topnost vgrajenih antioksidantov. Tako resveratrol kot tudi koencim Q10 po biofarmacevtskem klasifikacijskem sistemu uvrščamo v II. razred, saj imata oba slabo vodotopnost in dobro permeabilnost. Za izboljšanje dispergiranja obeh antioksidantov v vodni fazi smo uporabili metodo emulgiranja, in sicer smo resveratrol vgradili v emulzije tipa olje-v-vodi, ki so kot oljno fazo vsebovale srednje- (Captex 355) ali dolgoverižni (olivno olje) triglicerid. Pri koencimu Q10 smo zaradi nizke temperature tališča kot oljno fazo uporabili talino koencima Q10. Kot najboljši emulgator se je v obeh sistemih izkazal Tween 80. Vse emulzije smo pretvorili v hitro disperzibilne prahove, pri čemer smo kot trdni nosilec uporabili mezoporozni Syloid 244 FP. Emulzije z resveratrolom smo solidificirali s pomočjo sušenja z razprševanjem. Pri formulacijah s koencimom Q10 pa smo uporabili tudi ročno granuliranje s talino ter granuliranje s talino v hitro vrtečem mešalniku.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [A. Hren], 2022Language - slovenianCOBISS.SI-ID - 122629635
Author
Hren, Anja, farmacevtka
Other authors
Zvonar Pobirk, Alenka, 1980-
Topics
Topnost |
Ubikinon |
Antioksidanti |
disperzibilne formulacije |
emulgiranje |
sušenje z razprševanjem |
granuliranje s talinami |
koencim Q10 |
resveratrol
Library/institution |
City | Acronym | For loan | Other holdings |
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Faculty of Pharmacy, Ljubljana | Ljubljana | FFALJ |
reading room 1 cop.
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Hren, Anja, farmacevtka | |
Zvonar Pobirk, Alenka, 1980- | 26226 |
Source: Personal bibliographies
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