ALL libraries (COBIB.SI union bibliographic/catalogue database)
-
Determination of retinoids’ concentrations and paraoxonase 1 status in psychiatric patients treated with psychotropic drugs = Določitev koncentracij retinoidov in statusa encima paraoksonaza 1 pri bolnikih s psihiatričnimi obolenji, zdravljenih s psihotropnimi zdravili : Uniform Master's Study Programme PharmacyDebevec, EvaPsychiatric patients treated with psychotropic drugs are susceptible to metabolic alterations, prone to develop cardiovascular diseases (CVDs) and metabolic syndrome and present reduced life ... expectancy, generally due to the comorbid conditions. Oxidative stress and inflammation, along with various other factors, are present in the evolution and progression of psychiatric conditions, as well as CVDs. Retinoids and paraoxonase 1 (PON1) are involved in the regulation of oxidative stress, inflammation, and body metabolism and have been shown to be altered in psychiatric diseases. This study aimed to determine concentrations of retinoids retinol (RO) and retinyl palmitate (RePa) and PON1 status (PON1 activities and Q192R inferred genotype) in the serum of 73 psychiatric patients with a severe mental disorder and to assess whether the psychotropic treatment had an impact on RO serum concentrations and PON1 status. RO and RePa were determined by high-performance liquid chromatography with UV detection (HPLC-UV). PON1 lactonase, CMPAse, arylesterase, and saline arylesterase activities were determined spectrophotometrically, using non-organophosphate substrates dihydrocoumarin (DHC), 4-(chloromethyl)phenyl acetate (CMPA) and phenyl acetate (PA) in low and high salt conditions, respectively. PON1 Q192R genotype was inferred from a graph presenting CMPAse versus saline arylesterase activities. The measured RO concentrations were within the range of previously published studies in psychiatric patients. RePa levels did not suggest vitamin A toxicity or postprandial increase. Measured lactonase, CMPAse, arylesterase, and saline arylesterase activities were comparable to the existing studies in psychiatric patients. Functional genotype QQ was deduced in 32, QR in 32, and RR in 9 individuals, with allelic frequencies of 0.66 for Q and 0.34 for R allozyme and hence, correspond to those of Caucasian populations. Preliminary findings suggest that psychotropic drugs could affect serum RO concentrations and PON1 status. However, a further in-depth research is warranted. This study was a part of a broader on-going research project. Thus, the determined retinoid concentrations and PON1 status will be the subject of further research.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [E. Debevec], 2022Language - englishCOBISS.SI-ID - 123734531
Author
Debevec, Eva
Other authors
Pečar Fonović, Urša |
Mozo, Javier Esteban
Topics
Psihotropna zdravila |
retinoidi |
retinol |
paraoksonaza 1 |
status PON1 |
psihiatrični bolniki
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Library/institution |
City | Acronym | For loan | Other holdings |
---|---|---|---|---|
Faculty of Pharmacy, Ljubljana | Ljubljana | FFALJ |
reading room 1 cop.
|
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Debevec, Eva | ![]() |
Pečar Fonović, Urša | 19170 |
Mozo, Javier Esteban | ![]() |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: