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Surface modified magnetic nanoparticles for immuno-gene therapy of murine mammary adenocarcinomaPrijič, Sara ...Cancer immuno-gene therapy is an introduction of nucleic acids encoding immunostimulatory proteins, such as cytokine interleukin 12 (IL-12), into somatic cells to stimulate an immune response against ... a tumor. Various methods can be used for the introduction of nucleic acids into cells; magnetofection involves binding of nucleic acids to magnetic nanoparticles with subsequent exposure to an external magnetic field. Here we show that surface modified superparamagnetic iron oxide nanoparticles (SPIONs) with a combination of polyacrylic acid (PAA) and polyethylenimine (PEI) (SPIONs-PAA-PEI) proved to be safe and effective for magnetofection of cells and tumors in mice. Magnetofection of cells with plasmid DNA encoding reportergene using SPIONs-PAA-PEI was superior in transfection efficiency to commercially available SPIONs. Magnetofection of murine mammary adenocarcinoma with plasmid DNA encoding IL-12 using SPIONs-PAA-PEI resulted insignificant antitumor effect and could be further refined for cancer immuno-gene therapy.Source: Biomaterials. - ISSN 0142-9612 (Vol. 33, iss. 17, 2012, str. 4379-4391)Type of material - article, component partPublish date - 2012Language - englishCOBISS.SI-ID - 1237883
Author
Prijič, Sara |
Prosen, Lara |
Čemažar, Maja |
Ščančar, Janez |
Romih, Rok |
Lavrenčak, Jaka |
Bregar, Vladimir Boštjan |
Cör, Andrej |
Kržan, Mojca, 1962- |
Žnidaršič, Andrej, kemik, 1956-2011 |
Serša, Gregor
Topics
Mammary neoplasms, experimental |
Adenocarcinoma |
Gene therapy |
Nanotechnology |
Magnetics |
Interleukin-12 |
Transfection |
Polyethyleneimine |
nanoparticles |
gene therapy |
cytokine |
polyacrilic acid |
magnetism
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Prijič, Sara | 30724 |
Prosen, Lara | 33025 |
Čemažar, Maja | 14575 |
Ščančar, Janez | 18359 |
Romih, Rok | 11654 |
Lavrenčak, Jaka | 15819 |
Bregar, Vladimir Boštjan | 19411 |
Cör, Andrej | 11308 |
Kržan, Mojca, 1962- | 08095 |
Žnidaršič, Andrej, kemik, 1956-2011 | 10019 |
Serša, Gregor | 08800 |
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