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High-shear wet granulation of SMEDDS based on mesoporous carriers for Improved carvedilol solubility [Elektronski vir]Kovačević, Mila ...Mesoporous carriers are a convenient choice for the solidification of self-microemulsifying drug delivery systems (SMEDDS) designed to improve the solubility of poorly water-soluble drugs. They are ... known for high liquid load capacity and the ability to maintain characteristics of dry, free-flowing powders. Therefore, five different mesoporous carriers were used for the preparation of carvedilol-loaded SMEDDS granules by wet granulation methods—in paten (manually) and using a high-shear (HS) granulator. Granules with the highest SMEDDS content (63% and 66% of total granules mass, respectively) and suitable flow properties were obtained by Syloid® 244FP and Neusilin® US2. SMEDDS loaded granules produced by HS granulation showed superior flow characteristics compared to those obtained manually. All SMEDDS granules exhibited fast in vitro release, with 93% of carvedilol releasing from Syloid® 244FP-based granules in 5 min. Upon compaction into self-microemulsifying tablets, suitable tablet hardness and very fast disintegration time were achieved, thus producing orodispersible tablets. The compaction slightly slowed down the carvedilol release rate; nevertheless, upon 1 h (at pH 1.2) or 4 h (at pH 6.8) of in vitro dissolution testing, the amount of released drug was comparable with granules, confirming the suitability of orodispersible tablets for the production of the SMEDDS loaded single unit oral dosage formSource: Pharmaceutics [Elektronski vir]. - ISSN 1999-4923 (Vol. 14, iss. 10, art. 2077, 2022, 21 str.)Type of material - e-article ; adult, seriousPublish date - 2022Language - englishCOBISS.SI-ID - 123836163
Author | Kovačević, Mila ... |
Title | High-shear wet granulation of SMEDDS based on mesoporous carriers for Improved carvedilol solubility [Elektronski vir] |
Publication date | 2022-09-22 |
COBISS.SI-ID | 123836163 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
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Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin | P1-0208-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Link |
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https://www.mdpi.com/1999-4923/14/10/2077 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=141617 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Kovačević, Mila | |
German Ilić, Ilija, farmacevt | 28446 |
Bolko Seljak, Katarina, 1984- | 32694 |
Zvonar Pobirk, Alenka, 1980- | 26226 |
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