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  • Covalently conjugated NOD2/TLR7 agonists are potent and versatile immune potentiators [Elektronski vir]
    Guzelj, Samo ...
    The success of vaccination with subunit vaccines often relies on the careful choice of adjuvants. There is great interest in developing new adjuvants that can elicit a cellular immune response. Here, ... we address this challenge by taking advantage of the synergistic cross-talk between two pattern recognition receptors: nucleotide-binding oligomerization-domain-containing protein 2 (NOD2) and Toll-like receptor 7 (TLR7). We designed two conjugated NOD2/TLR7 agonists, which showed potent immunostimulatory activities in human primary peripheral blood mononuclear cells and murine bone-marrow-derived dendritic cells. One of these, 4, also generated a strong antigen-specific immune response in vivo, with a Th1-polarized profile. Importantly, our study shows that novel NOD2/TLR7 agonists elicit sophisticated and fine-tuned immune responses that are inaccessible to individual NOD2 and TLR7 agonists.
    Source: Journal of medicinal chemistry [Elektronski vir]. - ISSN 1520-4804 (Vol. 65, no. 22, 2022, str. 15085–15101)
    Type of material - e-article ; adult, serious
    Publish date - 2022
    Language - english
    COBISS.SI-ID - 128189187

    Link(s):

    https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.2c00808#
    Repository of the University of Ljubljana – RUL
    DOI

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