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Electrospinning as a method for preparation of redispersible dry product with high content of magnetic nanoparticlesDragar, Črt ...One of the key technological challenges in the development of iron-oxide-based magnetic nanoparticles (MNPs) is their long-term physical stability in colloidal dispersions. This can be improved by ... their transformation into a dry form. Here, we introduce electrospinning as a drying method for ethanol-based and water-based MNP dispersions, which enables the preparation of high-loaded dry MNP products. The obtained easily dispersible electrospun product contained up to 50 % (w/w) of MNPs, homogeneously distributed in the fibrillar structure, which is much more compared to the products of currently available methods for drying MNP dispersions. The polymers used as building blocks of nanofibers, namely poloxamer 188 and polyethylene oxide, improved the tolerance of MNPs to high ionic strength dispersion medium and thus enhanced the short-term physical stability of MNP dispersions after reconstitution. The dry product was stable for up to 1 month at room temperature and relative humidity up to 70 %. It was in the form of a nanofiber mat, which prevented the aerosolization of MNPs and their unintentional ambient exposure. Therefore, the electrospun product with MNPs is expected to be a safer dry formulation of MNPs than the nanoparticulate powders, which are usually the final products of the conventional drying methods.Source: International journal of pharmaceutics. - ISSN 0378-5173 (629, Vol. 629, 2022, str. 122389-1-122389-16)Type of material - article, component part ; adult, seriousPublish date - 2022Language - englishCOBISS.SI-ID - 130650883
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Author | Dragar, Črt ... |
Title | Electrospinning as a method for preparation of redispersible dry product with high content of magnetic nanoparticles |
Publication date | |
COBISS.SI-ID | 130650883 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
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Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih | P1-0189-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Napredna imunološka zdravila in celični pristopi v farmaciji | P1-0420-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Sodobni magnetni in večnamenski materiali | P2-0089-2020 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Izkoriščanje magneto-mehanskega učinka pri zdravljenju nevrodegenerativnih bolezni | J2-3043-2021 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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S posnemanjem endogenih lipidnih delcev do magnetno-odzivnih nanostruktur za izboljšano dostavo zdravil in nanodelcev | J2-3040-2021 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Selektivna elektroporacija s porazdeljenimi nanoelektrodami | J2-3046-2021 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Baktericidna nanorezila: preizkus bimodalnega mehanokemijskega odstranjevanja trdovratnih biofilmov | J3-3079-2021 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Nanoteranostiki na osnovi magnetno odzivnih materialov | J1-7302-2016 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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source: International journal of pharmaceutics. - ISSN 0378-5173 (629, Vol. 629, 2022, str. 122389-1-122389-16)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Dragar, Črt | 53585 |
Ileršič, Nives | ![]() |
Potrč, Tanja, farmacevtka | 37548 |
Nemec, Sebastjan, farmacevt | 52055 |
Kralj, Slavko, 1983- | 29529 |
Kocbek, Petra, farmacevtka | 24402 |
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