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Metabolične pregrade pri absorpciji učinkovin iz prebavnega trakta = Metabolic barriers at drug absorption from digestive tractPeternel, Luka ; Mrhar, Aleš ; Kristl, AlbinUčinkovine so ob prehodu iz prebavnega trakta v centralni krvni obtok podvržene predsistemskemu metabolizmu, zaradi česar je njihova biološka uporabnost znižana. Mesta predsistemskega metabolizma ... lahko poimenujemo tudi metaboli ne pregrade, ki jih delimo na jetra ter steno in lumen gastrointestinalnega trakta. Jetra so zaradi velike encimske zmogljivosti in svojevrstnega anatomskega poloæaja najpomembnejša metabolična pregrada. Stenagastrointestinalnega trakta je zaradi sinergisti nega delovanja med citokromom P450 3A4 in P-glikoproteinom za določene učinkovine glavno mesto predsistemskega metabolizma. Lumen gastrointestinalnega trakta je tudi pomembna metabolična pregrada zaradi prebavnih encimov, črevesne mikroflore in spremenljive pH vrednosti. S ciljem, da vključimo v proces razvoja novih u činkovin le spojine z visoko peroralno biološko uporabnostjo, je potrebno nakazati obseg predsistemskega metabolizma v posameznih metaboličnih pregradah že v zgodnjih fazah razvoja novih učinkovin.Source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Let. 54, št. 2, 2003, str. 189-198)Type of material - article, component partPublish date - 2003Language - slovenianCOBISS.SI-ID - 1324401
source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Let. 54, št. 2, 2003, str. 189-198)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Peternel, Luka | 24465 |
Mrhar, Aleš | 06086 |
Kristl, Albin | 11122 |
Source: Personal bibliographies
and: SICRIS
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