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Difference in methylation and expression of brain-derived neurotrophic factor in Alzheimer’s disease and mild cognitive impairment [Elektronski vir]Kouter, Katarina, 1989- ...Due to the increasing number of progressive dementias in the population, numerous studies are being conducted that seek to determine risk factors, biomarkers and pathological mechanisms that could ... help to differentiate between normal symptoms of aging, mild cognitive impairment (MCI) and dementia. The aim of this study was to investigate the possible association of levels of BDNF and COMT gene expression and methylation in peripheral blood cells with the development of Alzheimer’s disease (AD). Our results revealed higher expression levels of BDNF (p < 0.001) in MCI subjects compared to individuals diagnosed with AD. However, no difference in COMT gene expression (p = 0.366) was detected. DNA methylation of the CpG islands and other sequences with potential effects on gene expression regulation revealed just one region (BDNF_9) in the BDNF gene (p = 0.078) with marginally lower levels of methylation in the AD compared to MCI subjects. Here, we show that the level of BDNF expression in the periphery is decreased in subjects with AD compared to individuals with MCI. The combined results from the gene expression analysis and DNA methylation analysis point to the potential of BDNF as a marker that could help distinguish between MCI and AD patients.Source: Biomedicines [Elektronski vir]. - ISSN 2227-9059 (Vol. 11, iss. 2, 2023, str. 1-18)Type of material - e-article ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 138123267
Author
Kouter, Katarina, 1989- |
Nikolac Perković, Matea |
Nedic Erjavec, Gordana |
Milos, Tina |
Tudor, Lucija |
Uzun, Suzana |
Mimica, Ninoslav |
Pivac, Nela |
Videtič Paska, Alja, 1980-
Topics
epigenetics |
DNA methylation |
Alzheimer’s dementia |
epigenetika |
metilacija DNA |
Alzheimerjeva demenca
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Kouter, Katarina, 1989- | 38237 |
Nikolac Perković, Matea | ![]() |
Nedic Erjavec, Gordana | ![]() |
Milos, Tina | ![]() |
Tudor, Lucija | ![]() |
Uzun, Suzana | ![]() |
Mimica, Ninoslav | ![]() |
Pivac, Nela | ![]() |
Videtič Paska, Alja, 1980- | 27742 |
Source: Personal bibliographies
and: SICRIS
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