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Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surfaceJurišić Dukovski, Bisera ...Ophthalmic oil-in-water nanoemulsions (NEs) are a complex technological platform, representing an advancement in the treatment of dry eye disease. In addition to enabling the incorporation of poorly ... soluble active pharmaceutical ingredients (APIs), NEs provide prolonged residence time of APIs and other formulation components and consequent replenishment and stabilization of the compromised tear film. Ophthalmic NEs have been on the market for over 20 years, but considering their complexity, as well as the complex nature of the ocular surface, they are still a poorly understood advanced dosage form. The objective of this study was to develop a biorelevant in vitro method that would be able to predict the behavior of ophthalmic NEs after application. With that goal, NE formulations differing in critical material attributes and critical formulation variables were employed and subjected to simulated tear turnover and blinking. By gradually increasing the complexity of the in vitro method, we were able to detect key parameters influencing NE stability. The undertaken study presents a step forward in the development of in vitro tools that are fundamental to the reliable, cost and time-effective development of innovative and generic topical ophthalmic NEs.Source: International journal of pharmaceutics. - ISSN 0378-5173 (Vol. 633, art. 122622, 2023, 11 str.)Type of material - article, component part ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 139859459
Author
Jurišić Dukovski, Bisera |
Josip, Ljubica |
Kocbek, Petra, farmacevtka |
Safundžić Kučuk, Maša |
Krtalić, Iva, farmacevtka |
Hafner, Anita |
Pepić, Ivan |
Lovrić, Jasmina
Topics
Nanomateriali |
eye drops |
nanoemulsion |
chitosan |
dilution |
high shear |
dynamic light scattering |
kapljice za oko |
nanoemulzije |
dinamično sipanje svetlobe |
visoko striženje
Author | Jurišić Dukovski, Bisera ... |
Title | Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface |
Publication date | |
COBISS.SI-ID | 139859459 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
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FarmInova | IP-2019-04-2174 | ||
BioProspecting of the Adriatic Sea | BioProCro | KK.01.1.1.02 |
European Commission Croatian Science Foundation (CSF) |
Young researchers’ career development project – training of new doctoral students | DOK-2020-01-4932 |
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https://www.sciencedirect.com/science/article/pii/S037851732300042X |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=144061 |
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Jurišić Dukovski, Bisera | |
Josip, Ljubica | |
Kocbek, Petra, farmacevtka | 24402 |
Safundžić Kučuk, Maša | |
Krtalić, Iva, farmacevtka | |
Hafner, Anita | |
Pepić, Ivan | |
Lovrić, Jasmina |
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