ALL libraries (COBIB.SI union bibliographic/catalogue database)
-
8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases [Elektronski vir]Knez, Damijan, farmacevt ...We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase –hBChE) and monoamine oxidases ... (hMAO-A/B) for the therapy of neurodegenerative diseases. We identified QN 19, a simple, low molecular weight nitrone, that is readily synthesized from commercially available 8-hydroxyquinoline-2-carbaldehyde. Quinolylnitrone 19 has no typical pharmacophoric element to suggest ChE or MAO inhibition, yet unexpectedly showed potent inhibition of hBChE (IC50 = 1.06 ± 0.31 nmol/L) and hMAO-B (IC50 = 4.46 ± 0.18 μmol/L). The crystal structures of 19 with hBChE and hMAO-B provided the structural basis for potent binding, which was further studied by enzyme kinetics. Compound 19 acted as a free radical scavenger and biometal chelator, crossed the blood–brain barrier, was not cytotoxic, and showed neuroprotective properties in a 6-hydroxydopamine cell model of Parkinson’s disease. In addition, in vivo studies showed the anti-amnesic effect of 19 in the scopolamine-induced mouse model of AD without adverse effects on motoric function and coordination. Importantly, chronic treatment of double transgenic APPswe-PS1δE9 mice with 19 reduced amyloid plaque load in the hippocampus and cortex of female mice, underscoring the disease-modifying effect of QN 19.Source: Acta pharmaceutica sinica B. - ISSN 2211-3843 (Vol. 13, iss. 5, 2023, str. 2152-2175)Type of material - e-article ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 139883267
Author
Knez, Damijan, farmacevt |
Diez-Iriepa, Daniel |
Chioua, Mourad |
Gottinger, Andrea |
Meden, Anže |
Pišlar, Anja |
Kos, Janko, 1959- |
Žakelj, Simon |
Stojan, Jure, 1956- |
Gobec, Stanislav, 1970- |
Marco-Contelles, José
Topics
Nevrodegenerativne bolezni |
multifunkcionalni ligandi |
kinolilnitroni |
encimska kinetika
Author | Knez, Damijan, farmacevt ... |
Title | 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases [Elektronski vir] |
Publication date | 2023-05-01 |
COBISS.SI-ID | 139883267 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Goverment of Spain, MINECO | MINECO | SAF-2015- 65586-R | |
UCJC | OPTICOMC903 | OPTICOMC903 | |
UCJC | NACONT | NACONT | |
Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin | P1-0208-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Farmacevtska biotehnologija: znanost za zdravje | P4-0127-2019 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih | P1-0189-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Kovalentni zaviralci: zaviranje monoamin oksidaze preko nekatalitskih aminokislinskih ostankov | Z1-1859-2019 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Italia, Ministry of Education, University and Research | MIUR | MIUR | |
Spain, Ministry of Science, Innovation and Universities, predoctoral FPU grant | FPU grant | ||
France, Ministry of Armed Forces | NBC-5-C-421 |
Files that belong to the publication
Link |
---|
https://www.sciencedirect.com/science/article/pii/S2211383523000138 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=146733 |
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Knez, Damijan, farmacevt | 36438 |
Diez-Iriepa, Daniel | |
Chioua, Mourad | |
Gottinger, Andrea | |
Meden, Anže | 53584 |
Pišlar, Anja | 32035 |
Kos, Janko, 1959- | 04648 |
Žakelj, Simon | 22659 |
Stojan, Jure, 1956- | 03723 |
Gobec, Stanislav, 1970- | 15284 |
Marco-Contelles, José |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: