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Ibogaine-mediated ROS/antioxidant elevation in isolated rat uterus is β-adrenergic receptors and KATP channels mediated [Elektronski vir]Tatalović, Nikola ...Ibogaine effects are mediated by cellular receptors, ATP depletion followed by ROS production and antioxidant enzyme activity elevation in a dose and time dependent manner. Since the role of KATP ... channels and β-adrenoceptors in ROS cellular circuit was established here we explored their role in ibogaine pro-antioxidant effectiveness. Single dose of ibogaine (10 mg/L i.e., 28.8 μmol/L) was applied to isolated rat uterus (spontaneous and Ca2+-stimulated) and contractility and antioxidant enzymes activity were monitored during 4 h. Ibogaine increased amplitude and frequency of spontaneous active uteri immediately after addition that was prevented by propranolol (β1 and β2 adrenoceptors selective antagonists) and glibenclamide (KATP sensitive channels inhibitor; only frequency) pre-treatment. In Ca2+-stimulated uteri, ibogaine decreased both amplitude and frequency after 4 h. Pre-treatment with propranolol abolished ibogaine induced amplitude lowering, while glibenclamide had no effect. In both types of active uterus, ibogaine induced a decrease in SOD1 and an increase in CAT activity after 2 h. In Ca2+-stimulated uterus, there was also a decrease of SOD2 activity after 2 h. After 4 h, SOD1 activity returned to the baseline level, but GSH-Px activity increased. Pre-treatment with both propranolol and glibenclamide abolished observed changes of antioxidant enzymes activity suggesting that ibogaine pro-antioxidative effectiveness is β-adrenergic receptors and KATP channels mediated.Source: Antioxidants [Elektronski vir]. - ISSN 2076-3921 (Vol. 10, iss. 11, [article no.] 1792, 2021, 1-16 str.)Type of material - e-article ; adult, seriousPublish date - 2021Language - englishCOBISS.SI-ID - 140497923
Author
Tatalović, Nikola |
Vidonja-Uzelac, Teodora |
Oreščanin-Dušić, Zorana |
Nikolić-Kokić, Aleksandra |
Bresjanac, Mara |
Blagojević, Duško
Topics
ibogaine |
KATP channels |
glibenclamide |
β-adrenergic receptors |
propranolol |
antioxidative enzymes |
superoxide dismutase |
catalase |
uterus |
contractility |
ibogain |
KATP kanali |
glibenklamid |
β-adrenergični receptorji |
propranolol |
antioksidativni encimi |
superoksid dismutaza |
katalaza |
maternica |
kontraktilnost
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Tatalović, Nikola | ![]() |
Vidonja-Uzelac, Teodora | ![]() |
Oreščanin-Dušić, Zorana | ![]() |
Nikolić-Kokić, Aleksandra | ![]() |
Bresjanac, Mara | 10428 |
Blagojević, Duško | ![]() |
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