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(Z)-5-(4-fluorophenyl)pent-4-enoic acid : a precursor for convenient and efficient synthesis of the antihypercholesterolemia agent ezetimibe
Sova, Matej, 1979- ...
A convenient and efficient total synthesis of ezetimibe, an intestinal cholesterol absorption inhibitor and useful anticholesteremic agent, is described. Based on (Z)-5-(4-fluorophenyl)pent-4-enoic ...acid as a starting compound, and taking the synthesis through further Z-configured intermediates,the total yield is remarkably increased, compared with the use of the corresponding E-configured starting substances or intermediates.
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