-
The effect of design and size of the fluid-bed equipment on the particle size-dependent trend of particle coating thickness and drug prolonged-release profile [Elektronski vir]Brezovar, Teja ...The focus of the current work is to study and demonstrate the impact of the design, the scale, and settings of fluid-bed coating equipment on the differences in pellet coating thickness, which in ... case of prolonged-release pellets dictates the drug release. In the first set of coating experiments, the pellet cores were coated with the Tartrazine dye with the aim of estimating the coating equipment performance in terms of coating thickness distribution, assessed through color hue. In the second set, drug-layered pellets were film-coated with prolonged-release coating and dissolution profile tests were performed to estimate the thickness and uniformity of the coating thickness among differently sized pellets. In both study parts, film coating was performed at the laboratory and the pilot scale and essentially two types of distribution plate and different height adjustments of the draft tube were compared. The dye coating study proved to be extremely useful, as the results enable process correction and the optimal use of the process equipment in combination with the appropriate process parameters. Preferential film coating of larger drug-containing pellets was confirmed on the laboratory scale, while on the pilot scale, it was possible to achieve preferential coating of smaller pellets using rational alternatives of settings, which is desirable in terms of particle size-independent drug release profile of such prolonged-release dosage forms.Source: AAPS PharmSciTech [Elektronski vir]. - ISSN 1530-9932 (Vol. 24, iss. 4, art. 93, 2023, 16 str.)Type of material - e-article ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 147500291
Author
Brezovar, Teja |
Hudovornik, Grega, farmacevt |
Perpar, Matjaž, strojnik |
Luštrik, Matevž, doktor farmacije in dentalne medicine |
Dreu, Rok
Topics
Farmacevtska tehnologija |
Farmacevtske oblike |
pellet film coating |
Wurster chamber |
swirl generator |
prolonged release |
preferential coating |
peletna filmska prevleka |
Wursterjeva komora |
vrtinčni generator |
podaljšano sproščanje |
prednostna prevleka
Author | Brezovar, Teja ... |
Title | The effect of design and size of the fluid-bed equipment on the particle size-dependent trend of particle coating thickness and drug prolonged-release profile [Elektronski vir] |
Publication date | 2023-04-01 |
COBISS.SI-ID | 147500291 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih | P1-0189-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Tranzientni dvofazni tokovi (2009-2021) -> Večfazni sistemi (2022-2027) | P2-0162-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Files that belong to the publication
Link |
---|
https://link.springer.com/article/10.1208/s12249-023-02540-9 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=145071 |
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Brezovar, Teja | 37862 |
Hudovornik, Grega, farmacevt | 32217 |
Perpar, Matjaž, strojnik | 04471 |
Luštrik, Matevž, doktor farmacije in dentalne medicine | 31564 |
Dreu, Rok | 21455 |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.