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Relationship between excreted uremic toxins and degree of disorder of children with ASD [Elektronski vir]Osredkar, Joško, 1955- ...Autism spectrum disorder (ASD) is a complex developmental disorder in which communication and behavior are affected. A number of studies have investigated potential biomarkers, including uremic ... toxins. The aim of our study was to determine uremic toxins in the urine of children with ASD (143) and compare the results with healthy children (48). Uremic toxins were determined with a validated high-performance liquid chromatography coupled to mass spectrometry (LC-MS/MS) method. We observed higher levels of p-cresyl sulphate (pCS) and indoxyl sulphate (IS) in the ASD group compared to the controls. Moreover, the toxin levels of trimethylamine N-oxide (TMAO), symmetric dimethylarginine (SDMA), and asymmetric dimethylarginine (ADMA) were lower in ASD patients. Similarly, for pCS and IS in children classified, according to the intensity of their symptoms, into mild, moderate, and severe, elevated levels of these compounds were observed. For mild severity of the disorder, elevated levels of TMAO and comparable levels of SDMA and ADMA for ASD children as compared to the controls were observed in the urine. For moderate severity of ASD, significantly elevated levels of TMAO but reduced levels of SDMA and ADMA were observed in the urine of ASD children as compared to the controls. When the results obtained for severe ASD severity were considered, reduced levels of TMAO and comparable levels of SDMA and ADMA were observed in ASD children.Source: International journal of molecular sciences [Elektronski vir]. - ISSN 1422-0067 (Vol. 24, iss. 8, art. 7078, 2023, 14 str.)Type of material - e-article ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 148468227
Author
Osredkar, Joško, 1955- |
Žvar Baškovič, Barbara |
Finderle, Petra |
Bobrowska-Korczak, Barbara |
Gątarek, Paulina |
Rosiak, Angelina |
Giebułtowicz, Joanna |
Jekovec-Vrhovšek, Maja |
Kałużna-Czaplińska, Joanna
Topics
Motnje avtističnega spektra |
uremic toxins |
autism spectrum disorder |
ASD |
degree of deficit |
uremični toksini |
ASD |
stopnja primanjkljaja
Author | Osredkar, Joško, 1955- ... |
Title | Relationship between excreted uremic toxins and degree of disorder of children with ASD [Elektronski vir] |
Publication date | 2023-04-11 |
COBISS.SI-ID | 148468227 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Okoljski in genetski dejavniki pri motnjah avtističnega spektra | J3-1756-2019 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Metabolni in prirojeni dejavniki reproduktivnega zdravja, porod III | P3-0124-2020 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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https://www.mdpi.com/1422-0067/24/8/7078 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=145165 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Osredkar, Joško, 1955- | 10691 |
Žvar Baškovič, Barbara | |
Finderle, Petra | 30074 |
Bobrowska-Korczak, Barbara | |
Gątarek, Paulina | |
Rosiak, Angelina | |
Giebułtowicz, Joanna | |
Jekovec-Vrhovšek, Maja | 27697 |
Kałużna-Czaplińska, Joanna |
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