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  • Hydrogen-bonding ability of Noyori–Ikariya catalysts enables stereoselective access to ▫$1-CF_3$▫-substituted syn-1,2-diols via dynamic kinetic resolution
    Sterle, Maša ...
    Stereopure CF[sub]3-substituted syn-1,2-diols were prepared via the reductive dynamic kinetic resolution of the corresponding racemic α-hydroxyketones in HCO[sub]2H/Et[sub]3N. (Het)aryl, benzyl, ... vinyl, and alkyl ketones are tolerated, delivering products with ≥95% ee and ≥87:13 syn/anti. This methodology offers rapid access to stereopure bioactive molecules. Furthermore, DFT calculations for three types of Noyori–Ikariya ruthenium catalysts were performed to show their general ability of directing stereoselectivity via the hydrogen bond acceptor SO[sub]2 region and CH/π interactions.
    Source: ACS catalysis [Elektronski vir]. - ISSN 2155-5435 (no. 9, Vol. 13, 2023, str. 6242-6248)
    Type of material - e-article ; adult, serious
    Publish date - 2023
    Language - english
    COBISS.SI-ID - 150693379

    Link(s):

    https://pubs.acs.org/doi/10.1021/acscatal.3c00980
    Repository of the University of Ljubljana – RUL
    DOI

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