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Optimal process mode selection for clone screeningStrnad, Jure, 1982- ...A significant amount of data is generated during clone screening procedures because several cultivation systems are used such as well-plates, shake-flasks, laboratory-scale bioreactors among others. ... The amount of data can often be staggering and thus requires the use of statistical and data mining procedures in order to extract hidden information. In regard to a biosimilar monoclonal antibody project, data from the shake-flask scale was observed when comparing batch and fed-batch processes for several individual clones derived from two different cell lines. The aim of the research presented in this paper was to determine if clone selection based on batch data during the initial screening phase was equivalent to the results from fed-batch selection. It was determined that fed-batch processes should be implemented early during the screening procedure, if a choice is made that the final manufacturing process should also be operated in a fedbatch mode, as clone selection based on both batch and fed-batch analytical data was divergent.Source: Acta chimica slovenica. - ISSN 1318-0207 (Vol 58, no. 2, 2011, str. 333-341)Type of material - article, component partPublish date - 2011Language - englishCOBISS.SI-ID - 15110678
Author
Strnad, Jure, 1982- |
Spudić, Vatroslav |
Brinc, Matjaž, mikrobiolog |
Rozman Pungerčar, Jerica |
Kravanja, Zdravko
Topics
monoclonal antibody |
batch |
fed-batch |
clone screening |
glycosylation |
charge variants |
gensko inženirstvo |
monoklonska protitelesa |
šaržni reaktor |
procesni pogoji
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Strnad, Jure, 1982- | 28778 |
Spudić, Vatroslav | 34806 |
Brinc, Matjaž, mikrobiolog | 31061 |
Rozman Pungerčar, Jerica | 16411 |
Kravanja, Zdravko | 06005 |
Source: Personal bibliographies
and: SICRIS
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