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Effects of electrochemotherapy on immunologically important modifications in tumor cells [Elektronski vir]Kešar, Urša ...Electrochemotherapy (ECT) is a clinically acknowledged method that combines the use of anticancer drugs and electrical pulses. Electrochemotherapy with bleomycin (BLM) can induce immunogenic cell ... death (ICD) in certain settings. However, whether this is ubiquitous over different cancer types and for other clinically relevant chemotherapeutics used with electrochemotherapy is unknown. Here, we evaluated in vitro in the B16-F10, 4T1 and CT26 murine tumor cell lines, the electrochemotherapy triggered changes in the ICD-associated damage-associated molecular patterns (DAMPs): Calreticulin (CRT), ATP, High Mobility Group Box 1 (HMGB1), and four immunologically important cellular markers: MHCI, MHC II, PD-L1 and CD40. The changes in these markers were investigated in time up to 48 h after ECT. We showed that electrochemotherapy with all three tested chemotherapeutics induced ICD-associated DAMPs, but the induced DAMP signature was cell line and chemotherapeutic concentration specific. Similarly, electrochemotherapy with CDDP, OXA or BLM modified the expression of MHC I, MHC II, PD-L1 and CD40. The potential of electrochemotherapy to change their expression was also cell line and chemotherapeutic concentration specific. Our results thus put the electrochemotherapy with clinically relevant chemotherapeutics CDDP, OXA and BLM on the map of ICD inducing therapies.Source: Vaccines [Elektronski vir]. - ISSN 2076-393X (Vol. 11, no. 5, 2023, str. 925-1-925-22)Type of material - e-article ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 151344131
Author | Kešar, Urša ... |
Title | Effects of electrochemotherapy on immunologically important modifications in tumor cells [Elektronski vir] |
Publication date | 2023-04-30 |
COBISS.SI-ID | 151344131 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Elektrokemoterapija kot in situ vakcinacija | Z3-2651-2020 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Razvoj in ovrednotenje novih terapij za zdravljenje malignih tumorjev | P3-0003-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Cost type | Total cost | Payments |
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APC – Article Processing Charge | 2737.17 € |
2737.17 € : Onkološki inštitut Ljubljana |
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Kešar, Urša | 51873 |
Markelc, Boštjan | 32175 |
Jesenko, Tanja | 33227 |
Uršič Valentinuzzi, Katja, 1990- | 38223 |
Čemažar, Maja | 14575 |
Strojan, Primož | 14576 |
Serša, Gregor | 08800 |
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