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  • Phosphonate inhibitors of antigen 85C, a crucial enzyme involved in the biosynthesis of the Mycobacterium tuberculosis cell wall
    Gobec, Stanislav, 1970- ...
    The first phosphonate inhibitors of antigen 85C--a major protein component of the Mycobacterium tuberculosis cell wall possessing mycolyltransferase activity were prepared using structure-based ... design. These potential novel antituberculosis agents, consisting of a phosphonate moiety, hydrophobic alkylchain and a simple trehalose-mimicking aromatic structure, were designed as tetrahedral transition-state analogue inhibitors of antigen 85C, which catalyzes the key mycolyltransferase reaction involved in cell wall biosynthesis
    Source: Bioorganic & Medicinal Chemistry Letters. - ISSN 0960-894X (Vol. 14, no. 13, 2004, str. 3559-3562)
    Type of material - article, component part
    Publish date - 2004
    Language - english
    COBISS.SI-ID - 1513585

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