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Suitability of RPMI 2650 cell models for nasal drug permeability predictionSibinovska, Nadica ; Žakelj, Simon ; Kristan, Katja, 1975-The RPMI 2650 cell line has been a subject of evaluation as a physiological and pharmacological model of the nasal epithelial barrier. However, its suitability for drug permeability assays has not ... yet been established on a sufficiently large set of model drugs. We investigated two RPMI 2650 cell models (air-liquid and liquid-liquid) for nasal drug permeability determination by adopting the most recent regulatory guidelines on showing suitability of in vitro permeability methods for drug permeability classification. The permeability of 23 model drugs and several zero permeability markers across the cell models was assessed. The functional expression of two efflux transporters P-glycoprotein (P-gp) and Breast Cancer Resistant Protein (BCRP) was shown to be negligible by bidirectional transport studies using appropriate transporter substrates and inhibitors. The model drug permeability determined in the two RPMI 2650 cell models was correlated with the fully differentiated nasal epithelial model (MucilAir%). Additionally, correlations between the drug permeability in the investigated cell models and the ones determined in the Caco-2 cells and isolated rat jejunum were established. In conclusion, the air-liquid RPMI 2650 cell model is a promising pharmacological model of the nasal epithelial barrier and is much more suitable than the liquid-liquid model for nasal drug permeability prediction.Source: European journal of pharmaceutics and biopharmaceutics. - ISSN 0939-6411 (Vol. 145, 2019, str. 85-95)Type of material - article, component part ; adult, seriousPublish date - 2019Language - englishCOBISS.SI-ID - 1518174
Author
Sibinovska, Nadica |
Žakelj, Simon |
Kristan, Katja, 1975-
Topics
RPMI 2650 |
Air-liquid interface |
Liquid-liquid interface
source: European journal of pharmaceutics and biopharmaceutics. - ISSN 0939-6411 (Vol. 145, 2019, str. 85-95)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Sibinovska, Nadica | |
Žakelj, Simon | 22659 |
Kristan, Katja, 1975- | 24392 |
Source: Personal bibliographies
and: SICRIS
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