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Nanooblaganje-možnosti in prednostiHomar, Miha ; Kristl, JulijanaPostopki nanooblaganja omogoèajo izdelavo obloge, katerih debelina je v obmoèju od nekaj deset do nekaj sto nanometrov. Izredna tankost obloge predstavlja veliko prednost pri oblaganju vsadkov ter ... farmacevtskih oblik mikrometrskih velikosti, ki so namenjene predvsem parenteralni in pulmunalni aplikaciji. Sam prispevek obloge h konènemu volumnu in masi farmacevtske oblike ali vsadka je minimalen, modifikacija povrsinskih lastnosti kot posledica obloge pa lahko moèno vpliva na obnasanje v organizmu. Najpomembnejsa lastnost nanooblog je izboljsanje bioloske kompatibilnosti, karpomeni, da pripravki v telesu ne povzroèajo nezazelenih reakcij, hkrati pa zmanjsamo oz. odstranimo interakcijo z imunskim sistemom, kar podaljsuje èas nahajanja farmacevtskih oblik v organizmu oz. zivljenjsko dobo vsadkov. Nanoobloge lahko z modifikacijo povrsine pospesijo obnavljanje in rast tkiva, ter izboljsajo mehanske lastnosti pripravkov (poveèana stabilnost farmacevtskih oblik v krvnem obtoku, poveèanje trdnosti kostnih vsadkov). Zraven vsega nastetega lahko nanoobloge uporabimo podobno kot klasiène obloge za uravnavanje sprosèanja, zasèito uèinkovine, ciljano dostavo, itd. Poznamo veè naèinov oblaganja, kot sta npr. sol-gel metoda in plast-za-plastjo metoda.Z njimi je mogoèe izdelati homogene obloge tudi na kompleksnih povrsinah, debelina obloge, ter posledièno njene lastnosti, pa so odvisne od uporabljene metode oblaganja in snovi, ki smo jih uporabili za izdelavo obloge.Source: Nanotehnologija v farmaciji : zbornik referatov, Ljubljana 10. junij 2004 (str. 65-79)Type of material - conference contribution ; adult, seriousPublish date - 2004Language - slovenianCOBISS.SI-ID - 1525873
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Database name | Field | Year |
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Homar, Miha | 25600 |
Kristl, Julijana | 09032 |
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