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Napredek zdravljenja bolnikov z razsejanim rakom debelega črevesa in danke z vidika internista onkologaOcvirk, JanjaMetastatski rak debelega črevesa in danke je v večini primerov še vedno neozdravljiva bolezen, vendar pa sta se prognoza ter preživetje teh bolnikov močno izboljšala v zadnjem desetletju. Od ... srednjega desetmesečnega preživetja, ki smo ga dosegali z zdravljenjem s 5-fluorouracilom, ki je bilo do pred nekaj leti edino učinkovito zdravilo za zdravljenje teh bolnikov, smo prešli na preživetja daljša od 20 mesecev, kar so omogočila nova citostatska zdravila. V zadnjih desetih letih je bilo registriranih šest novih zdravil za zdravljenje matastatskega raka debelega črevesa in danke: citostatiki - kapecitabin, irinotekan, oksaliplatin in tarčna zdravila - cetuksimab, bevacizumab in panitumumab. Kombinirano zdravljenje omogoča boljšo kakovost življenja in daljše remisije, s tem pa tudi daljša celotna preživetja. Uporaba kombinacije citostatikov s tarčnimi zdravili vodi še v nadaljnje podaljšanje srednjega preživetja teh bolnikov, tako zdravljeni bolniki imajo srednja preživetja daljša od 30 mesecev. Tovrstno zdravljenje, v kombinaciji z operacijo pljučnih ali jetrnih zasevkov, pa omogoča tudi zazdravitve. Pomembno je določanje mutacij na genu KRAS. Za kolorektalni rak je gen KRAS prvi biomarker, ki napoveduje, kako se bodo bolniki odzvali na zdravljenja z EGFR inhibitorji.Source: Šola tumorjev prebavil, Ljubljana, 30. 11. 2012 (Letn. 17, št. 1, jun. 2013, str. 39-43, 76)Type of material - conference contributionPublish date - 2013Language - slovenianCOBISS.SI-ID - 1555067
Author
Ocvirk, Janja
Topics
razsejani rak |
rak debelega črevesa |
rak danke |
internistična onkologija
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source: Šola tumorjev prebavil, Ljubljana, 30. 11. 2012 (Letn. 17, št. 1, jun. 2013, str. 39-43, 76)
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Ocvirk, Janja | 13541 |
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