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Kvantitativni odnos med strukturo in delovanjem (QSAR) peptidomimetikov s 3,4-dihidro-2H-1,4-benzooksazinskim skeletom = Quantitative structure activity relationsip (QSAR) of peptidomimetic agents with 3,4-dihidro-2H-1,4-benzooxazine scaffold : diplomska naloga
Perdih, Andrej, farmacevt
Hemostaza ima pomembno vlogo pri ohranjanju integritete delovanja krvozilnega sistema. Posledica patoloskih sprememb tega sistema so razlièni kardiovaskularni zapleti, kot so miokardni infarkt, ...ishemièna mozganska kap, embolije, tromboze ipd., kar predstavlja enega glavnih vzrokov za smrt v razvitem svetu. Zato poteka neprestan razvoj uèinkovin, ki se vpletajo v proces hemostaze. Zelo obetavne nove zdravilne uèinkovine so tudi antagonisti fibrinogenskega GP IIbžIIIa receptorja in inhibitorji koagulacijskega faktorjastrjevanja krvi - trombina. Antagonisti fibrinogenskega GP IIbžIIIa prepreèujejo vezavo naravnega liganda fibrinogena in tako inhibirajo agregacijo trombocitov. Z inhibicijo trombina pa prepreèimo nastanek fibrina in s tem premrezenje in stabilizacijo agregiranih trombocitov. Zelo aktualen pa je tudi razvoj uèinkovin z dualnim mehanizmom delovanja na obe tarèi.
Type of material - undergraduate thesis
Publication and manufacture - Ljubljana : [Perdih, A.], 2004
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