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  • Response of monocyte-derived dendritic cells to rapidly solidified nickel-titanium ribbons with shape memory properties [Elektronski vir]
    Tomić, Sergej ...
    Ni-Ti Shape Memory Alloys (SMAs) have attracted considerable attention as biomaterials for medical devices. However, the biocompatibility of Ni-Ti SMAs is often unsatisfactory due to their poor ... surface structure. Here we prepared Rapidly Solidifi ed (RS) Ni-Ti SMA ribbons by melt-spinning and their surface was characterised by Augerelectron spectroscopy, X-ray photoelectron spectrometry and scanning electron microscopy. The biocompatibility of the produced ribbons and their immunomodulatory properties were studied on human monocyte-derived dendritic cells (MoDCs). We showed that melt-spinning of Ni-Ti SMAs can form a thin homogenous oxide layer, which improves their corrosion resistance and subsequent toxicity to MoDCs. Ni-Ti RS ribbons stimulated the maturation of MoDCs, as detected by changes in the cellsć morphology and increased expression of HLA-DR, CD86, CD40 and CD83 molecules. However, Ni-Ti RS ribbons enhanced the tolerogenic properties of immature MoDCs, which produced higher levels of IL-10 and IL-27, driving the differentiation of IL-10- and TGF-â-producing CD4+T cells. On the other hand, in the presence of lipopolysaccharide, an important pro-infl ammatory biomolecule, Ni-Ti RS ribbons enhanced the allostimulatory and Th1 polarising capacity of MoDCs, whereas the production of Th2 and Th17 cytokines was down-regulated. In conclusion, Ni- Ti RS ribbons possess substantial immunomodulatory properties on MoDCs. These fi ndings might be clinically relevant, because implanted Ni-Ti SMA devices can induce both desired and adverse effects on the immune system, depending on the microenvironmental stimuli.
    Source: European cells & materials [Elektronski vir]. - ISSN 1473-2262 (Vol. 23, Jan.-June 2012, str. 58-80)
    Type of material - e-article
    Publish date - 2012
    Language - english
    COBISS.SI-ID - 15705366

    Link(s):

    http://www.ecmjournal.org/journal/papers/vol023/vol023a05.php
    Digital Library of the University of Maribor – DLUM

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