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Response of monocyte-derived dendritic cells to rapidly solidified nickel-titanium ribbons with shape memory properties [Elektronski vir]Tomić, Sergej ...Ni-Ti Shape Memory Alloys (SMAs) have attracted considerable attention as biomaterials for medical devices. However, the biocompatibility of Ni-Ti SMAs is often unsatisfactory due to their poor ... surface structure. Here we prepared Rapidly Solidifi ed (RS) Ni-Ti SMA ribbons by melt-spinning and their surface was characterised by Augerelectron spectroscopy, X-ray photoelectron spectrometry and scanning electron microscopy. The biocompatibility of the produced ribbons and their immunomodulatory properties were studied on human monocyte-derived dendritic cells (MoDCs). We showed that melt-spinning of Ni-Ti SMAs can form a thin homogenous oxide layer, which improves their corrosion resistance and subsequent toxicity to MoDCs. Ni-Ti RS ribbons stimulated the maturation of MoDCs, as detected by changes in the cellsć morphology and increased expression of HLA-DR, CD86, CD40 and CD83 molecules. However, Ni-Ti RS ribbons enhanced the tolerogenic properties of immature MoDCs, which produced higher levels of IL-10 and IL-27, driving the differentiation of IL-10- and TGF-â-producing CD4+T cells. On the other hand, in the presence of lipopolysaccharide, an important pro-infl ammatory biomolecule, Ni-Ti RS ribbons enhanced the allostimulatory and Th1 polarising capacity of MoDCs, whereas the production of Th2 and Th17 cytokines was down-regulated. In conclusion, Ni- Ti RS ribbons possess substantial immunomodulatory properties on MoDCs. These fi ndings might be clinically relevant, because implanted Ni-Ti SMA devices can induce both desired and adverse effects on the immune system, depending on the microenvironmental stimuli.Source: European cells & materials [Elektronski vir]. - ISSN 1473-2262 (Vol. 23, Jan.-June 2012, str. 58-80)Type of material - e-articlePublish date - 2012Language - englishCOBISS.SI-ID - 15705366
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Tomić, Sergej | ![]() |
Rudolf, Rebeka | 14335 |
Brunčko, Mihael | 20229 |
Anžel, Ivan, inženir metalurgije in materialov | 10369 |
Savić, V., Medicina | ![]() |
Čolić, Miodrag | ![]() |
Source: Personal bibliographies
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