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Viscoelastic properties of fibrinogen adsorbed onto poly (ethylene terephthalate) surfaces by QCM-D
Doliška, Aleš ...
In presented study a new approach using QCM-D for biocompatibility determination was introduced. The adsorption of fibrinogen on PET and modified PET surfaces was monitored in-situ using QCM-D. ...Protein layer thicknesses were estimated on the basis of a Voight based viscoelastic model. The hydrophylicities and morphologies of the surfaces were investigated using a goniometer and AFM. The results showed that PET surfaces coated with sulphated polysaccharides are more hydrophilic and more fibrinogen-repulsive than non-modified PET surfaces. QCM-D equipped with QTools modelling software is well-applicable to the characterisation of surface properties and can be optimised for biocompatibility determination.
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