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Vznik in razvoj karcinoma v luči spoznanj molekularne genetike
Ferluga, Dušan, 1934- ...
Cancer is basically the result of accumulating genetic damage. Carcinogenesis in humans is a long-term multistage process which includes initiation, promotion and progression. Initiation is ...characterized by mutation of genes regulating cell growth, replication, differentiation, and apoptosis. Cell proliferation implicated in promotion by epigenetic events enables fixation ofgenetic damage. Clonal expression of cells acquiring a selective growth advantage plays an important role in carcinogenesis. Progression primarily involves genes regulating cell adhesion molecules and production of proteases.Steadily increasing knowledge about growth factors, signal transduction pathways, and cancer genes contributes to the better understanding of carcinogenesis.
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