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13.
Imunski mehanizmi nutritivne alergije = Immunological mechanisms of food allergy
Ihan, Alojz
Food allergy is an adverse reaction to foods that is mediated immunologically.Clinical manifestations of food allergy include symptoms of the gastrointestinal, cutaneous and respiratory systems, as ...well as systemic anaphylaxis. Although food hypersensitivity might be divided in IgE- and non-IgE mediated food allergy, there is a large body of evidence implicating Tlymphocytes overall in the pathogenesis of food allergy. Priming of naive T cells will occur mainly in Peyer's patches (PP), where surface receptors will help to initiate migration of the cells to the submucosa. Various antigen-presenting cells (e.g. dendritic cells, M cells) will present food antigen-derived epitopes and initiate either non-responsiveness, or a food-mediated immune response. The development of food - specific T helper 1 (Th1) versus Th2 cells is a major branch point in the immune response. It is an important determinant of whether the response to food will lead to tolerance or hypersensitive reactions.
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