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Piritramid for postoperative pain management after supratentorial craniotomy
Visočnik, Božidar ...
The aim of this study was to determine piritramid pooperative analgesic Efficacy and side effects in patients after supratentorial craniotomy. Twenty patients entered the study. General anaesthesia ...was standardized with propofoland remifentanil, 30 minutes before the end of surgery, all patients received 5 -15 mg piritramid and 2.5 g metamizol intravenously. After the end of surgery patients received piritramid 1 mg per hour in continual intravenousinfusion for the next 24 hours. Postoperative pain was assessed in the fully awake patients 30 min. after extubation and at 6 and 24 hours using a visual analog scale NAS). Additional piritramid (2.5 -10 mg) was administered when the VAS score was > 3. Adverse effects of the piritramid (nausea/ vomiting, high blood pressure) were also registered.30 min. after extubation the mean VAS was 2.35 (1- 5). Six patients had VAS > 3 and needed an additional dose of piritramid. The mean dose was 5.16 mg (3 -10 mg) of piritramid. Six hours after extubation the mean VAS was 2.05 (0 - 6) aod five patients required an additional dose of piritramid (mean dose was 5.4 mg). Twenty four hours after exrubations the mean VAS was 0.6. None of the patientsneeded additional analgesic therapy. Seven patients (35 %) had nausea/vomiting and four (20 degrees/) patieofs had hypertension. We have cometo conclusion that piritramid seems to be a safe and effective analgetic for post craniotomy pain control.
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