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Nanodelci kot nosilci siRNA v terapiji rakaMurovec, AnikaPoleg tradicionalnih metod zdravljenja raka so zaradi neželenih učinkov, odpornosti na zdravljenje in ponovnega pojava raka potrebni novi in manj agresivni pristopi za zdravljenje bolezni. Mala ... interferenčna RNA (siRNA) predstavlja obetavno alternativno možnost za zdravljenje raka, saj je manj toksična od tradicionalnih pristopov, kot je kemoterapija. Ena izmed glavnih prednosti terapij z malo interferenčno RNA je sposobnost ciljanja kateregakoli gena. Glavna omejitev pri terapiji s siRNA je nezadosten privzem v celice, kar se kaže v slabi učinkovitosti terapije. Omejitve pri terapiji oz. sistemski dostavi siRNA predstavljajo še slaba stabilnost med cirkulacijo in neoptimalna farmakokinetika ter biodistribucija siRNA in vivo. Zato je treba molekule siRNA kompleksirati ali konjugirati z ustreznim nosilnim sistemom. Nanodelci so se v zadnjem času izkazali kot optimalni nosilni sistem za dostavo siRNA, zato je to področje trenutno zelo aktualno in se z njim ukvarjajo številni raziskovalci. Z uporabo nanodelcev s siRNA bi tako lahko uspešno premagali ovire pri zdravljenju s siRNA in s tem razvili nov način zdravljenja raka.Source: Placebo : strokovna revija DŠFS in ŠSSFD. - ISSN 2820-5006 (št. 2, sep. 2023, str. 39-44)Type of material - article, component part ; adult, seriousPublish date - 2023Language - slovenianCOBISS.SI-ID - 166099715
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Murovec, Anika |
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