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Experimental and theoretical model for the origin of coiling of cellular protrusions around fibers [Elektronski vir]Kumar Sadhu, Raj ...Protrusions at the leading-edge of a cell play an important role in sensing the extracellular cues during cellular spreading and motility. Recent studies provided indications that these protrusions ... wrap (coil) around the extracellular fibers. However, the physics of this coiling process, and the mechanisms that drive it, are not well understood. We present a combined theoretical and experimental study of the coiling of cellular protrusions on fibers of different geometry. Our theoretical model describes membrane protrusions that are produced by curved membrane proteins that recruit the protrusive forces of actin polymerization, and identifies the role of bending and adhesion energies in orienting the leading-edges of the protrusions along the azimuthal (coiling) direction. Our model predicts that the cell’s leading-edge coils on fibers with circular cross-section (above some critical radius), but the coiling ceases for flattened fibers of highly elliptical cross-section. These predictions are verified by 3D visualization and quantitation of coiling on suspended fibers using DualView light-sheet microscopy (diSPIM). Overall, we provide a theoretical framework, supported by experiments, which explains the physical origin of the coiling phenomenon.Source: Nature communications [Elektronski vir]. - ISSN 2041-1723 (Vol. 14, [article no.] 5612, 2023, str. 1-13)Type of material - e-article ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 166115587
Author
Kumar Sadhu, Raj |
Hernandez-Padilla, Christian |
Eshed Eisenbach, Yael |
Penič, Samo |
Zhang, Lixia, elektrotehničarka |
Vishwasrao, Harshad D. |
Behkam, Bahareh |
Konstantopoulos, Konstantinos |
Shroff, Hari |
Iglič, Aleš, 1960- |
Peles, Elior |
Nain, Amrinder S. |
Gov, Nir S.
Topics
mobilnost celice |
računalniške simulacije |
metoda Monte Carlo |
fizikalni model proteinov |
cell motility |
computer simulations |
Monte Carlo method |
physical protein model
Author | Kumar Sadhu, Raj ... |
Title | Experimental and theoretical model for the origin of coiling of cellular protrusions around fibers [Elektronski vir] |
Publication date | 2023-09-12 |
COBISS.SI-ID | 166115587 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Unidentified |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
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Collaborative Research: Mechanobiology of Fiber Geometry-RhoGTPase Crosstalk at the Leading Edge of Cells Crawling on Fibers | 1762634 |
National Science Foundation |
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Collaborative Research: Theory and experiment of contact inhibition of locomotion in nanofiber geometries | 2119949 |
National Science Foundation |
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III:Medium:Physics-guided Machine Learning for Predicting Cell Trajectories, Shapes, and Interactions in Complex Dynamic Environments | 2107332 |
National Science Foundation |
|
Analiza biomedicinskih slik in signalov | P2-0232-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Optimizacija s trombociti in zunajceličnimi vezikli bogate avtologne krvne plazme za zdravljenje pooperativnih ran v otorinolaringologiji | J3-3066-2021 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Vpliv mehanike in topologije membrane na celično ujetje bakterij, virionov in anorganskih delcev | J2-4447-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Files that belong to the publication
Link |
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https://www.nature.com/articles/s41467-023-41273-y |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=155480 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Kumar Sadhu, Raj | |
Hernandez-Padilla, Christian | |
Eshed Eisenbach, Yael | |
Penič, Samo | 28467 |
Zhang, Lixia, elektrotehničarka | |
Vishwasrao, Harshad D. | |
Behkam, Bahareh | |
Konstantopoulos, Konstantinos | |
Shroff, Hari | |
Iglič, Aleš, 1960- | 04634 |
Peles, Elior | |
Nain, Amrinder S. | |
Gov, Nir S. |
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