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  • Design and synthesis of novel platelet fibrinogen receptor antagonists with 2H-1,4-benzoxazine-3(4H)-one scaffold. A systematic study
    Anderluh, Marko ...
    New platelet glycoprotein IIbžIIIa (GP IIbžIIIa, integrin ŽIIbß3) antagonists were prepared on a 2H-1,4-benzoxazine-3(4H)-one scaffold. Their anti-aggregatory activities in human platelet rich plasma ... and their affinity towards ŽIIbß3 and ŽVß3 integrins were assessed. Various substitution positions and side chain variations were studied. In contrast to the generallyaccepted model, compounds containing ethyl esters as aspartate mimetics were in general more active than the corresponding free acids. We suggest an explanation for the observed behaviour of these new compounds.
    Source: European journal of medicinal chemistry. - ISSN 0223-5234 (Vol. 40, no. 1, 2005, str. 25-41)
    Type of material - article, component part
    Publish date - 2005
    Language - english
    COBISS.SI-ID - 1670001

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