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Physical properties and dissolution behaviour of nifedipine/mannitol solid dispersions prepared by hot melt method
Zajc, Natalija, 1974- ...
Solid dispersions of nifedipine (NIF) with mannitol in preparations containing10 and 50% (wžw) of drug were manufactured by the hot melt method. Physical properties and the dissolution behaviour of ...binary systems as physical mixtures and solid dispersions were investigated. In all samples, thecrystal structure of NIF was confirmed using differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). Fourier transform infrared spectroscopy (FTIR) revealed, there was no interaction between drug and carrier, however, FTIR spectra indicated formation of thermodynamically less stable polymorph of mannitol. The dissolution rate of NIF from solid dispersions was markedly enhanced, the effect being stronger at higher drug loading (50%, wžw, NIF). The dissolution rate enhancement was attributed to improved wetting of NIF crystals due to mannitol particles, attached on the surface, as inspected by means of SEM. Thermal stability of NIF, mannitol and two other potential carbohydrate carriers (lactose and saccharose) during the hot melt procedure was investigated using 1H NMR. NIF was found to be thermically stable under conditions applied. As expected, among carriers only mannitol demonstrated suitable resistance to high temperature used in experiments.
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