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  • Azapeptides as pharmacological agents
    Zega, Anamarija
    Azapeptides, formed by replacing the C of amino acid residues by nitrogen, are promising peptidomimetic compounds. Azaamino acids impart a unique conformational property to peptide structures because ... of the loss of chiralityand reduction of flexibility of the parent linear peptide. The peculiar conformational properties make azaamino acids an attractive tool for drug design involving specific secondary structures in peptides and proteins. Additionally, since azapeptides are less susceptible to enzymatic breakdown byproteases, they may possibly lead to orally active drugs with longer duration of action. One of the advantages of azapeptides is their unproblematic synthesis allowing retention of the amino acid side chain. Azapeptides have been developed by several groups for the design of hormone analogues, protease inhibitors and active site titrants.
    Source: Current medicinal chemistry. - ISSN 0929-8673 (Vol. 12, no. 5, 2005, str. 589-599)
    Type of material - article, component part
    Publish date - 2005
    Language - english
    COBISS.SI-ID - 1694065

source: Current medicinal chemistry. - ISSN 0929-8673 (Vol. 12, no. 5, 2005, str. 589-599)
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