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  • Association on metabolic gene polymorphisms with tobacco consumption in healthy controls
    Smits, Kim M. ...
    Polymorphisms in genes that encode for metabolic enrymes have been associated with variations in enryme activity between individuals. Such variations could be associated with differences in ... individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens wasused. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20,938). Sufficient information was availableon the following genes that are invohed in the metabolism of tobacco smoke constituents: CYP1A1, GSTM1, GSTT1, NAT2 and GSTP1. None of the tested genes was clearly associated with smoking behavior. information on smoking dose, available for a subset of subjects, showed no etfect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking 6ehavior should 6e expected.
    Source: International journal of cancer = Journal international du cancer. - ISSN 0020-7136 (Letn. 110, 2004, str. 266-270)
    Type of material - article, component part
    Publish date - 2004
    Language - english
    COBISS.SI-ID - 17849305

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