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Cognitive functioning is prognostic in patients with IDH1-wild type and MGMT-unmethylated high-grade gliomasSmrdel, Uroš ...To investigate the prognostic factors of survival in patients with high-grade gliomas without isocitrate dehydrogenase- 1 (IDH) mutation and O6-methylguanine-DNA methyltransferase (MGMT) promoter ... methylation. Methods The study enrolled Slovenian patients with highgrade gliomas. Postoperatively, they completed a battery of neuropsychological tests. Demographics and clinical data were collected. The results of cognitive tests were converted to standardized scores and dichotomized based on impairment. A univariate Cox proportional hazard regression model was used to determine clinical predictors, and a multivariate Cox model was used to determine the prognostic value of cognitive test results. Kaplan-Meier curves were constructed, and survival was compared with the log rank test. Results The study enrolled 49 patients with IDH wild-type, MGMT-unmethylated high-grade gliomas. The median time to progression was 9.92 months (7.25, 12.59) and the overall median survival was 12.19 months (8.95, 15.4). Age and the extent of surgery were significant prognostic factors for survival. After controlling for these factors, cognitive functioning in the domain of verbal fluency remained a significant predictor of survival outcomes. Conclusion Cognitive functioning in the domain of verbal fluency was associated with overall survival independently of age and the extent of surgery. Cognitive functioning could be an important stratifying tool in this group of patients lacking other predictors.Source: Croatian medical journal. - ISSN 0353-9504 (Vol. 64, no. 6, 2023, str. 383-390)Type of material - article, component part ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 180953347
Author
Smrdel, Uroš |
Škufca Smrdel, Andreja Cirila |
Podlesek, Anja |
Skoblar Vidmar, Marija |
Kos, Gregor, zdravnik |
Markovič, Jana, 1978- |
Jereb, Jana, 1989- |
Knific, Jana, dr. med., psih. |
Rus, Tina, psihologinja, 1990-
Topics
high-grade gliomas |
prognostic factors |
survival |
cognitive functioning |
gliomi visokega gradusa |
napovedni dejavniki |
preživetje |
kognitivne funkcije
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Database name | Field | Year |
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Smrdel, Uroš | 20176 |
Škufca Smrdel, Andreja Cirila | 20177 |
Podlesek, Anja | 18919 |
Skoblar Vidmar, Marija | 32723 |
Kos, Gregor, zdravnik | ![]() |
Markovič, Jana, 1978- | ![]() |
Jereb, Jana, 1989- | ![]() |
Knific, Jana, dr. med., psih. | 56869 |
Rus, Tina, psihologinja, 1990- | ![]() |
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