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Inhibition of MurA enzyme from Escherichia coli by flavonoids and their synthetic analogues [Elektronski vir]Frlan, Rok ; Hrast, Martina ; Gobec, Stanislav, 1970-MurA catalyzes the first step of peptidoglycan (PG) biosynthesis and is a validated target for the development of new antimicrobial agents. In this study, a library of 49 plant flavonoids and their ... synthetic derivatives were evaluated for their inhibitory properties against MurA fromEscherichia coli. The compounds were tested with and without preincubation and with the addition of DTT to understand the mechanism of inhibition. Thirteen compounds were identified as reversible, time-dependent inhibitors, with inhibition levels ranging from 480 nM to 57 μM, and ampelopsin as the most potent compound. To investigate the major pharmacophore elements responsible for the activity, 2D-QSAR and docking analyzes were performed. The results showed that the catechol moiety and an additional aromatic system were the most important features contributing to the activity of the compounds. However, most of the compounds did not show antibacterial activity againstE. coli and Staphylococcus aureusstrains, suggesting that their inhibitory activity against MurA may not be strong enough to induce antibacterial effects. Nevertheless, our results suggest that flavonoids are a promising starting point to develop new inhibitors of MurA and show great potential for further steps in drug development.Source: ACS omega [Elektronski vir]. - ISSN 2470-1343 (Vol. 8, no. 36, 2023, str. 33006-33016)Type of material - e-article ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 181848835
Author
Frlan, Rok |
Hrast, Martina |
Gobec, Stanislav, 1970-
Topics
Flavonoidi |
Bakterijska rezistenca |
Peptidi |
Beljakovine |
assays |
flavonoids |
inhibition |
inhibitors |
peptides |
proteins |
testi |
inhibicija |
zaviralci |
proteini
Author | Frlan, Rok ; Hrast, Martina ; Gobec, Stanislav, 1970- |
Title | Inhibition of MurA enzyme from Escherichia coli by flavonoids and their synthetic analogues [Elektronski vir] |
Publication date | |
COBISS.SI-ID | 181848835 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin | P1-0208-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Razvoj protibakteriskih učinkovin z delovanjem na validirane tarče v biosintezi peptidoglikana | J1-2484-2020 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Files that belong to the publication
Link |
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https://pubs.acs.org/doi/10.1021/acsomega.3c04813 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=154069 |
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Frlan, Rok | 26512 |
Hrast, Martina | 32036 |
Gobec, Stanislav, 1970- | 15284 |
Source: Personal bibliographies
and: SICRIS
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