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Correlating mechanical and rheological filament properties to processability and quality of 3D printed tablets using multiple linear regressionKreft, Klemen ...Filament formulation for FDM is a challenging and time-consuming process. Several pharmaceutical polymers are not feedable on their own. Due to inadequate filament formulation, 3D printed tablets can ... also exhibit poor uniformity of tablet attributes. To better understand filament formulation process, 23 filaments were prepared with the polymer mixing approach. To yield processable filaments, brittle and pliable polymers were combined. A 20 % addition of a pliable polymer to a brittle one resulted in filament processability and vice versa. Predictive statistical models for filament processability and uniformity of tablet attributes were established based on the mechanical and rheological properties of filaments. 15 input variables were correlated to 9 responses, which represent filament processability and tablet properties, by using multiple linear regression approach. Filament stiffness, assessed by indentation, and its square term were the only variables that determined the filament’s feedability. However, the resulting model is equipment-specific since different feeding mechanism exert different forces on the filaments. Additional models with good predictive power (R2pred > 0.50) were established for tablet width uniformity, drug release uniformity, tablet disintegration time uniformity and occurrence of disintegration, which are equipment-independent outputs. Therefore, the obtained model outcomes could be used in other research endeavours.Source: International journal of pharmaceutics. - ISSN 0378-5173 (Vol. 651, 2024, 14 str.)Type of material - article, component part ; adult, seriousPublish date - 2024Language - englishCOBISS.SI-ID - 182047747
Author
Kreft, Klemen |
Lavrič, Zoran |
Gradišar Centa, Urška |
Mihelčič, Mohor |
Slemenik Perše, Lidija |
Dreu, Rok
Topics
Personalizirana medicina |
Farmacevtska tehnologija |
fused deposition modelling |
personalized medicine |
multiple linear regression |
tablet quality attributes |
correlation |
3D printing |
modeliranje taljenega nanosa |
personalizirana medicina |
večkratna linearna regresija |
atributi kakovosti tabličnega računalnika |
korelacija |
3D tiskanje
Author | Kreft, Klemen ... |
Title | Correlating mechanical and rheological filament properties to processability and quality of 3D printed tablets using multiple linear regression |
Publication date | |
COBISS.SI-ID | 182047747 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution-NoDerivatives 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih | P1-0189-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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https://www.sciencedirect.com/science/article/pii/S0378517323011419 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=154070 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Kreft, Klemen | 54293 |
Lavrič, Zoran | 32037 |
Gradišar Centa, Urška | 36365 |
Mihelčič, Mohor | 33498 |
Slemenik Perše, Lidija | 22701 |
Dreu, Rok | 21455 |
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