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Formulation containing dexketoprofen and tramadol and method for making the same [Elektronski vir] : EP4188337A1·2023-06-07
Škrlec, Katja, farmacevtka ...
The present invention provides pharmaceutical compositions comprising dexketoprofen and tramadol, which are stable and easy to manufacture. The pharmaceutical compositions of the present invention ...are characterized by dexketoprofen being provided in an intragranular phase and tramadol being provided in an extragranular phase or vice versa. In addition, the present invention provides a simple method for manufacturing such pharmaceutical compositions. The key aspect of the manufacturing method according to the present invention is the preparation of a granulate containing dexketoprofen or, in another embodiment, tramadol by means of dry granulation, prior to admixing of tramadol, or in the other embodiment dexketoprofen, and optional further excipients. Medical uses of the pharmaceutical compositions of the present invention are also provided.
Type of material - patent application
; adult, serious
Publication and manufacture - München : European Patent Office, 2022
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