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Pharmaceutical formulation of metformin having low content of dimethylamine [Elektronski vir] : WO2022023213A1·2022-02-03Žnideršič, Luka ...A metformin starting material for incorporation into a pharmaceutical dosage form comprising metformin or a physiologically acceptable salt thereof, wherein the content of metformin is at least 99.0 ... wt- %, relative to the total weight of the metformin starting material, wherein the material has a content of dimethylamine of not more than 180 ppm, relative to the weight of metformin, and wherein metformin is present as a powder having a volume median diameter D(50) of not more than 200 um, determined by laser diffraction analysis. A process for the preparation of a metformin starting material, the process comprising the steps of : (i) providing metformin or a physiologically acceptable salt thereof; ( ii) grinding the metformin or physiologically acceptable salt thereof thereby obtaining ground metformin or physiologically acceptable salt thereof; and(iii) subjecting the metformin or physiologically acceptable salt thereof, or the ground metformin or physiologically acceptable salt thereof, to elevated temperature and/or reduced pressure thereby obtaining dried metformin or physiologically acceptable salt thereof. A process for the preparation of a pharmaceutical dosage form comprising metformin or a physiologically acceptable salt thereof and having a content of N-nitroso dimethylamine of not more than 48 ppb, relative to the total weight of metformin in the pharmaceutical dosage form, wherein the process comprises the aforementioned process.Type of material - patent application ; adult, seriousPublication and manufacture - München : European Patent Office, 2022Language - englishCOBISS.SI-ID - 182824195
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Žnideršič, Luka | ![]() |
Šenica, Luka | 34346 |
Gabrič, Alen | ![]() |
Bombek, Sergeja | 21343 |
Korasa, Klemen | 37880 |
Repič, Matej | 33210 |
Vrhunc, Gašper | ![]() |
Hodnik, Žiga, farmacevt | 33052 |
Buzar, Ilija | ![]() |
Source: Personal bibliographies
and: SICRIS
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