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Zdravljenje presnovnega sindroma z zdravili
Medvešček, Marko
Metabolic syndrome is a cluster of obesity, hypertension, dislipidemia, and hyperglycemia. It is is closely linked to visceral adiposity and insulin resistance, accompanied by procoagulant, ...proinflammatory state, endothelial dysfunction and other atherogenic abnormalities. Individuals with the metabolic syndrome are at higher risk for cardiovascular disease and type 2 diabetes. Therapeutic lifestyle modification and treatment of all cardiovascular risk factors is the strategy to prevent cardiovascular diseas and diabetes. LDL cholesterol lowering is the primary goal in indivuiduals with the metabolic syndrome and dislipidemia. As far as antihypertensive treatment is concerned, the choice of the agent should avoid the clearly diabetogenic drugs. Among the drugs, which can improve insulin resistance, arethiazolidinediones, which also have numerous other antiatherogenic effects,separate from their antihyperglicemic effect. Results of longlasting controlled clinical studies with these drugs on the risk of cardiovascular diseas are being awaited, and the decision of their use in metabolic syndrome is depending largely on the outcome of these studies.
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