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KATP-channels in beta-cells in tissue slices are directly modulated by millimolar ATPSpeier, Stephan ...In pancreatic beta-cells, inhibition of K(ATP)-channels plays a pivotal role in signal transduction of glucose-induced insulin release. However, the extreme sensitivity of K(ATP)-channels to its ... ligand ATP as found in inside-out patches is not directly compatible with modulation of these channels at physiological [ATP](i). We studied K(ATP)-channel sensitivity to ATP in beta-cells in dispersed culture and in fresh pancreatic tissue slices. Physiological [ATP](i) blocks more than 99% of K(ATP)-channels in cultured beta-cells, while only 90% in beta-cells in slices, indicating reduced sensitivity to ATP in the fresh slices. Applying cytosolic factors like ADP, phosphatidylinositol-4,5-bisphosphate (PIP(2)) or oleoyl-CoA did not restore the K(ATP)-channel sensitivity in cultured beta-cells. Our data suggest that interaction between SUR1 and Kir6.2 subunit of the K(ATP)-channel could be a factor in sensitivity modulation. Tissue slices are the first beta-cell preparation to study direct K(ATP)-channel modulation by physiological [ATP](i).Source: Molecular and cellular endocrinology. - ISSN 0303-7207 (Vol. 230, no. 1-2, 2005, str. 51-58)Type of material - article, component part ; adult, seriousPublish date - 2005Language - englishCOBISS.SI-ID - 1878591
Author
Speier, Stephan |
Yang, Shi-Bing |
Sroka, Kamila |
Rose, Tobias |
Rupnik, Marjan
Topics
Potassium channels |
Islets of Langerhans |
Oleoyl |
ATP |
Insulin |
Mice
source: Molecular and cellular endocrinology. - ISSN 0303-7207 (Vol. 230, no. 1-2, 2005, str. 51-58)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Speier, Stephan | |
Yang, Shi-Bing | |
Sroka, Kamila | |
Rose, Tobias | |
Rupnik, Marjan | 12266 |
Source: Personal bibliographies
and: SICRIS
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